SKN | Entrée Capital Launches $300M Fund Targeting AI Agents and DePIN Infrastructure

Entrée Capital has launched a new $300 million investment fund aimed at accelerating early-stage development across crypto, artificial intelligence and decentralized infrastructure. The firm said the fund will focus on founders building core layers that enable mainstream Web3 adoption, particularly where AI and blockchain technologies converge.

A Push Toward AI-Driven Financial Automation

The firm plans to back teams from pre-seed through Series A that are developing AI agents capable of autonomously managing assets within cryptographically enforced policy frameworks. Entrée believes these AI systems will become essential components of next-generation financial architecture, offering institutions a path toward secure, automated decision-making across digital markets.

Entrée’s partners said institutional conversations are increasingly centered on utility and autonomy rather than experimentation. As organizations seek systems that integrate seamlessly with existing finance and compliance workflows, AI-enabled asset management is emerging as one of the most compelling use cases.

Growing Momentum Behind DePIN Networks

Alongside AI agents, the new fund prioritizes decentralized physical infrastructure (DePIN) networks blockchain-powered systems that coordinate, deploy and fund real-world infrastructure through token incentives. Entrée expects DePIN to become a key technological primitive as demand grows for more distributed compute, storage and connectivity.

These networks function as crypto-native counterparts to cloud computing, enabling scalable infrastructure with lower operational costs and transparent economic incentives. Entrée described decentralized compute and autonomous finance as “mainstream technology primitives in the making.”

Institutional Appetite Arrives

Entrée Capital said its track record in fintech and crypto gives it a strong vantage point as institutional capital begins to shift toward automated systems and real-world utility. The firm previously backed Stripe, Rapyd, Mesh, and Web3 builders such as Gen Labs and Breez, and believes the next wave of innovation will emerge from founders building at the intersection of regulated finance and decentralized networks.

The fund launch reflects a broader trend: institutions are increasingly exploring AI-enabled financial infrastructure and decentralized compute as durable technologies rather than speculative experiments. Entrée expects this convergence to define the next decade of Web3 development.